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Cytoplasmic carboxy-terminal STIM protein domains contain a uniquely configured group of -helical sequences that form an activating domain able to bind to and gate the Orai channel in the plasma membrane

However, substantial interindividual variability in therapeutic response remains a significant challenge for clinical application [260, 261]

Moreover, due to the relative genomic stability of mtDNA within a tumor, its mutational landscape can serve as a molecular fingerprint

(Cochrane Metabolic and Endocrine Disorders Group) (June 2020)

In addition, mitochondrial protease Lon peptidase 1 (LONP1) inhibits Nrf2-mediated GPX4 gene expression, thereby promoting Erastin-induced ferroptosis in human PDAC cells (Wang H